2×TransStart® FastPfu Fly PCR SuperMix (-dye)

Referência AS231-01-V4

Tamanho : 1ml

Marca : TransGen Biotech

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ProteinFind® Anti-CD105 Mouse Monoclonal Antibody

Catalog Number: HS905-01

Price:Please inquire first

Specification:
20 µl

Product Details

CD105, also known as endothelial glycoprotein, is a homodimer transmembrane protein linked by disulfide bonds. CD105 is a co-receptor of TGF-β receptor complex and plays a role in related signal transduction pathways[1,2]. CD105 is highly expressed in vascular endothelial cells and is a marker molecule of tumor angiogenesis[3]. In addition, CD105 is also expressed on the surface of activated monocytes and macrophages[4]. It plays an important role in angiogenesis regulation[5,6]. This product is the mouse anti-human CD105 monoclonal antibody, which is used for the specific detection of human CD105 by FC.


Storage

PBS (pH7.4), 0.05% ProClin 300, 50% Glycerol; at -20oC for two years, avoid repeated freeze-thawing.


Shipping

Dry ice (-70℃)


References

[1]  Bernabeu C, Conley BA, Vary CPH. Novel biochemical pathways of endoglin in vascular cell physiology [J]. Journal of  Cellular Biochemistry. 2007, 102(6): 1375-88.

[2] Zhu Y, Sun Y, Xie L, et al. Hypoxic induction of endoglin via mitogen-activated protein kinases in mouse brain microvascular endothelial cells [J]. Stroke. 2003, 34(10): 2483-8.

[3] Fonsatti E, Sigalotti L, Arslan P, et al. Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies [J]. Curr Cancer Drug Targets. 2003, 3(6): 427-32.

[4] Lastres P, Bellon T, Cabañas C, et al. Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen [J]. Eur J Immunol. 1992, 22(2): 393-7. 

[5] Castonguay R, Werner ED, Matthews RG, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth [J]. J Biol Chem. 2011, 286(34): 30034-46. 

[6] Nolan-Stevaux O, Zhong W, Culp S, et al. Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies [J]. PLoS One. 2012, 7(12): e50920.


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