Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and sonic hedgehog intracellular signaling. The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of beta-Galactosidase expression in Ptch(-/-) cells.||Solubility: |As reported ||Melting Point:|As reported ||Atmosphere: |Inert gas||Method for Determining Identity: Proton NMR (CD30D) Spectroscopic and Mass Spectrometric Analysis||TLC Conditions:|As reported ||Storage and Stability:|May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |Light, temperature and moisture sensitive. Solutions are not stable.||Important Note: |This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.||Toxicity and Hazards:|All products should be handled by qualified personnel only, trained in laboratory procedures.