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> 4-Bromo-A23187 [76455-48-6]

4-Bromo-A23187 [76455-48-6]

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Referência 10-5590-5mg

Tamanho : 5mg

Marca : Focus Biomolecules

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4-Bromo-A23187 | Non-fluorescent calcium ionophore

CAS:
76455-48-6
Catalog Number:
10-5590
Activity:
Non-fluorescent calcium ionophore
Chemical Names:
4-Bromocalcimycin
Alternate Name:
4-Bromo-calcium ionophore A23187
Molecular Weight:
602.53
Molecular Formula:
C29H36BrN3O6
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size: Quantity 
1 mg$110.00
5 mg$475.00
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4-Bromo-A23187 (76455-48-6) is a non-fluorescent analog1 of calcium ionophore A-231872 which may be used in experiments employing fluorescent probes to avoid interference3,4. Off-target effects include uncoupling of oxidative phosphorylation5 and inhibition of SR Ca2+-ATPase6.

References/Citations:

  1. Deber et al. (1985) Bromo-A23187: A nonfluorescent calcium ionophore for use with fluorescent probes; Anal. Biochem. 146 349
  2. Reed and Lardy (1972) A23187: a divalent cation ionophore; J.  Biol. Chem. 247 6970
  3. Wesseling et al. (2016) Phosphatidylserine Exposure in Human Red Blood Cells Depending on Cell Age; Cell Physiol. Biochem. 38 1376
  4. Yang et al. (2013) NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells; J. Biol. Chem. 288 16960
  5. Wong et al. (1973) Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria; Arch.  Biochem. Biophys. 156 578
  6. Hara and Kanazawa (1986) Selective inhibition by ionophore A23187 of the enzyme isomerization in the catalytic cycle of sarcoplasmic reticulum Ca2+-ATPase; J.  Biol. Chem. 261 16584
CAS:
76455-48-6
Catalog Number:
10-5590
Activity:
Non-fluorescent calcium ionophore
Chemical Names:
4-Bromocalcimycin
Alternate Name:
4-Bromo-calcium ionophore A23187
Molecular Weight:
602.53
Molecular Formula:
C29H36BrN3O6
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

4-Bromo-A23187 (76455-48-6) is a non-fluorescent analog1 of calcium ionophore A-231872 which may be used in experiments employing fluorescent probes to avoid interference3,4. Off-target effects include uncoupling of oxidative phosphorylation5 and inhibition of SR Ca2+-ATPase6.

References/Citations:

  1. Deber et al. (1985) Bromo-A23187: A nonfluorescent calcium ionophore for use with fluorescent probes; Anal. Biochem. 146 349
  2. Reed and Lardy (1972) A23187: a divalent cation ionophore; J.  Biol. Chem. 247 6970
  3. Wesseling et al. (2016) Phosphatidylserine Exposure in Human Red Blood Cells Depending on Cell Age; Cell Physiol. Biochem. 38 1376
  4. Yang et al. (2013) NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells; J. Biol. Chem. 288 16960
  5. Wong et al. (1973) Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria; Arch.  Biochem. Biophys. 156 578
  6. Hara and Kanazawa (1986) Selective inhibition by ionophore A23187 of the enzyme isomerization in the catalytic cycle of sarcoplasmic reticulum Ca2+-ATPase; J.  Biol. Chem. 261 16584