Anti-CD28 antibody (Clone: 204.12)

Clonality:	Monoclonal
Clone ID:	204.12
Conjugation:	Unconjugated
Isotype:	IgG2b
Formulation:	PBS with 0.02% sodium azide
Concentration:	100 ug/mL
Dilution Range:	FC 0 5-1 0 µg/million cells in 0 1 ml-IF 0 5-1 0 µg/ml-IHC frozen 1-2 µg/ml for 30-60 min at RT
Storage Instruction:	Store at 2-8°C upon receipt.

Gene Symbol:	CD28
Gene ID:	940
Uniprot ID:	CD28_HUMAN
Immunogen:	Stimulated human leucocytes

Tissue Specificity	Expressed in T-cells and plasma cells, but not in less mature B-cells.
Post Translational Modifications	CD40LG induces tyrosine phosphorylation of isoform 3.
Function	Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
Protein Name	T-Cell-Specific Surface Glycoprotein Cd28 Tp44 Cd Antigen Cd28
Database Links	Reactome: R-HSA-1257604 Reactome: R-HSA-164939 Reactome: R-HSA-2219530 Reactome: R-HSA-389356 Reactome: R-HSA-389357 Reactome: R-HSA-389359 Reactome: R-HSA-6811558
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein Isoform 3: Cell Surface
Alternative Antibody Names	Anti-T-Cell-Specific Surface Glycoprotein Cd28 antibody Anti-Tp44 antibody Anti-Cd Antigen Cd28 antibody Anti-CD28 antibody

Information sourced from Uniprot.org

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