Anti-CD45/Ptprc antibody (Clone: OX-1) {PE/Cyanine7}

Clonality:	Monoclonal
Clone ID:	OX-1
Conjugation:	PE/Cyanine7
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	Ptprc
Gene ID:	24699
Uniprot ID:	PTPRC_RAT

Tissue Specificity	Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod.
Post Translational Modifications	Heavily N- and O-glycosylated. The cytoplasmic domain contains potential phosphorylation sites.
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
Protein Name	Receptor-Type Tyrosine-Protein Phosphatase C Leukocyte Common Antigen L-Ca T200 Cd Antigen Cd45
Database Links	Reactome: R-RNO-202427 Reactome: -RNO-416700 Reactome: -RNO-6798695
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft Colocalized With Dpp4 In Membrane Rafts
Alternative Antibody Names	Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibody Anti-Leukocyte Common Antigen antibody Anti-L-Ca antibody Anti-T200 antibody Anti-Cd Antigen Cd45 antibody Anti-Ptprc antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance