Anti-CD71/Tfrc antibody (Clone: R17 217.1.3/TIB-219) {APC}

Clonality:	Monoclonal
Clone ID:	R17 217.1.3/TIB-219
Conjugation:	APC
Isotype:	IgG2ak
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Concentration:	0.2 mg/mL
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	Tfrc
Gene ID:	22042
Uniprot ID:	TFR1_MOUSE

Post Translational Modifications	Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation. Stearoylation does not affect iron uptake. N- and O-glycosylated, phosphorylated and palmitoylated.
Function	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2.
Protein Name	Transferrin Receptor Protein 1 Tr Tfr Tfr1 Trfr Cd Antigen Cd71
Database Links	Reactome: R-MMU-432722 Reactome: -MMU-8856825 Reactome: -MMU-8856828 Reactome: -MMU-8980692 Reactome: -MMU-9013026 Reactome: -MMU-9013106 Reactome: -MMU-9013149 Reactome: -MMU-9013404 Reactome: -MMU-9013406 Reactome: -MMU-9013407 Reactome: -MMU-9013408 Reactome: -MMU-9013423 Reactome: -MMU-917977 Reactome: -MMU-9696270 Reactome: -MMU-9696273
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Melanosome
Alternative Antibody Names	Anti-Transferrin Receptor Protein 1 antibody Anti-Tr antibody Anti-Tfr antibody Anti-Tfr1 antibody Anti-Trfr antibody Anti-Cd Antigen Cd71 antibody Anti-Tfrc antibody Anti-Trfr antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance