Tamanho : 100ug
Telefone : +1 850 650 7790
| Size : | Quantity | ||
|---|---|---|---|
| 100 ug | $40.00 | ||
| 1 mg | $172.00 |
Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via disruption of fusion between autophagosomes and lysosomes.3
References/Citations:
1) Werner et al. (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot., 37 110
2) Drose and Altendorf (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase; J. Exp. Biol., 200 1
3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells; Cell Struct. Func., 23 33
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Bafilomycin A1 (88899-55-2) is a macrolide antibiotic derived from Streptomyces griseus that is a potent and selective inhibitor of vacuolar H+-ATPases (IC50 = 0.6 – 1.5 nM).1,2 Bafilomycin A1 inhibits autophagy via disruption of fusion between autophagosomes and lysosomes.3
References/Citations:
1) Werner et al. (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot., 37 110
2) Drose and Altendorf (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase; J. Exp. Biol., 200 1
3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells; Cell Struct. Func., 23 33
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