CD44, Fc Fusion, Recombinant, Human, aa21-220 (Epican, Extracellular Matrix Receptor III, GP90 Lymphocyte Homing/Adhesion Receptor, HUTCH-I, Phagocytic Glyco-Protein I, PGP-1, Homing Cell Adhesion Molecule, HCAM)

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].||Source:|Recombinant protein corresponding to aa21-220 from human CD44 at C-terminal, fused with Fc region of human IgG, expressed in HEK293 cell expression system.||Molecular Weight: |~48.7kD, protein runs at a higher MW by SDS-PAGE due to glycosylation||Endotoxin:|<1EU/ug||Applications: |Suitable for use in studying protein binding and for screening small molecules and antibodies. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.