CD79A (208-222) Mouse Monoclonal Antibody [Clone ID: HM47]
Referência AM26759AC-N
Tamanho : 100Tests
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| Product Data | |
| Clone Name | HM47 |
|---|---|
| Application | FC |
| Application | Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
| Reactivity | Bovine, Canine, Chicken, Equine, Guinea Pig, Human, Mouse, Porcine, Primate, Rabbit, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a |
| Specificity | This antibody reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms. |
| Buffer | Phosphate buffered saline (PBS) Label: APC State: Liquid purified Ig fraction Preservative: 15 mM sodium azide Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. |
| Conjugation | APC |
| Storage | Store undiluted the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
| Stability | Shelf life: one year from despatch. |
| Gene Name | CD79a molecule |
| Database Link | |
| Background | CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. |
| Synonyms | IGA, MB1, B-Cell marker |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.