General Info
| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Cell Surface Glycoprotein MUC18 Positive Control for STJ501820 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:2, 500-1:5, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Mcam |
| Gene ID: | 78967 |
| Uniprot ID: | MUC18_RAT |
| Specificity: | This is positive control is recommended for use in combination with Cell Surface Glycoprotein MUC18 antibody STJ501820. |
| Immunogen: | Purified Protein |
Description
| Tissue Specificity | Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippocampus, olfactory bulb and striatum (at protein level). |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Peptide Name | Cell Surface Glycoprotein Muc18GicerinMelanoma Cell Adhesion MoleculeMelanoma-Associated Antigen Muc18Cd Antigen Cd146 |
| Database Links | Reactome: R-RNO-8980692Reactome: -RNO-9013026Reactome: -RNO-9013106Reactome: -RNO-9013149Reactome: -RNO-9013404Reactome: -RNO-9013405Reactome: -RNO-9013408Reactome: -RNO-9013423Reactome: -RNO-9035034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPerikaryonDetected At The Surface Of The Cell Body Of Motor Neurons |
| Alternative Peptide Names | Cell Surface Glycoprotein Muc18 proteinGicerin proteinMelanoma Cell Adhesion Molecule proteinMelanoma-Associated Antigen Muc18 proteinCd Antigen Cd146 proteinMcam proteinMuc18 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance