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Reagentes e instrumentos para imunologia, biologia celular e biologia molecular.

Chamaechromone [93413-00-4]

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Referência HY-133721-5mg

Tamanho : 5mg

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Marca : MedChemExpress

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Telefone : +1 850 650 7790

Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses anti-hepatitis B virus (HBV) effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities.

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Chamaechromone Chemical Structure

CAS No. : 93413-00-4

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Description

Masse moléculaire

542.49

Formule

C₃₀H₂₂O₁₀

CAS No.

93413-00-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(C=C1)=CC=C1C(C2=CC=C(C=C2)O)C(C3=COC4=CC(O)=CC(O)=C4C3=O)C(C5=C(C=C(C=C5O)O)O)=O

Structure Classification

Flavonoids
Biflavones

Phenols
Polyphenols

Initial Source

Plants
Thymelaeaceae
Stellera chamaejasme L.

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (184.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8434 mL	9.2168 mL	18.4335 mL
5 mM	0.3687 mL	1.8434 mL	3.6867 mL
10 mM	0.1843 mL	0.9217 mL	1.8434 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: 99.81%

Select Batch:

SDS (251 KB)

COA (255 KB) HNMR (265 KB) LCMS (254 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Yan Lou, et al.Metabolites characterization of chamaechromone in vivo and in vitro by using ultra-performance liquid chromatography/Xevo G2 quadrupole time-of-flight tandem mass spectrometry. J Ethnopharmacol [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8434 mL	9.2168 mL	18.4335 mL	46.0838 mL
	5 mM	0.3687 mL	1.8434 mL	3.6867 mL	9.2168 mL
	10 mM	0.1843 mL	0.9217 mL	1.8434 mL	4.6084 mL
	15 mM	0.1229 mL	0.6145 mL	1.2289 mL	3.0723 mL
	20 mM	0.0922 mL	0.4608 mL	0.9217 mL	2.3042 mL
	25 mM	0.0737 mL	0.3687 mL	0.7373 mL	1.8434 mL
	30 mM	0.0614 mL	0.3072 mL	0.6145 mL	1.5361 mL
	40 mM	0.0461 mL	0.2304 mL	0.4608 mL	1.1521 mL
	50 mM	0.0369 mL	0.1843 mL	0.3687 mL	0.9217 mL
	60 mM	0.0307 mL	0.1536 mL	0.3072 mL	0.7681 mL
	80 mM	0.0230 mL	0.1152 mL	0.2304 mL	0.5760 mL
	100 mM	0.0184 mL	0.0922 mL	0.1843 mL	0.4608 mL

Chamaechromone Related Classifications

Inflammation/Immunology Infection

Anti-infection
HBV

Chamaechromone [93413-00-4]

Referência HY-133721-5mg

Contactar o distribuidor local :

Marca : MedChemExpress

Contactar o distribuidor local :

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Chamaechromone Related Classifications

Keywords: