EGFR Human Gene Knockout Kit (CRISPR)
Referência KN214877LP
Tamanho : 1kit
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EGFR Human Gene Knockout Kit (CRISPR)
SKU
KN214877LP
EGFR - human gene knockout kit via CRISPR, HDR mediated
4 Weeks*
| Product Data | |
| Format | 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control |
|---|---|
| Vector | Luciferase-Puro |
| Target Symbol | EGFR |
| Locus ID | 1956 |
| Components | KN214877G1, EGFR gRNA vector 1 in pCas-Guide CRISPR vector KN214877G2, EGFR gRNA vector 2 in pCas-Guide CRISPR vector KN214877LPD, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
| Reference Data | |
| RefSeq | NM_005228, NM_201282, NM_201283, NM_201284, NM_001346897, NM_001346898, NM_001346899, NM_001346900, NM_001346941 |
| UniProt ID | P00533 |
| Synonyms | ERBB; ERBB1; HER1; mENA; NISBD2; PIG61 |
| Summary | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020] |
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| SDS |
| SKU | Description | Size | ||
|---|---|---|---|---|
| GA101355 | EGFR CRISPRa kit - CRISPR gene activation of human epidermal growth factor receptor | 1 kit | | |
| KN214877 | EGFR - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN214877BN | EGFR - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN214877RB | EGFR - human gene knockout kit via CRISPR, HDR mediated | 1 kit | | |
| KN414877 | EGFR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 kit | | |
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.