GC376 Sodium [1416992-39-6]
Referência AOB36447-50
Tamanho : 50mg
Marca : AOBIOUS
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Data sheet
| Molecular Formula | C21H30N3NaO8S |
| Molecular Weight | 507.53 |
| CAS Numbers | 1416992-39-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | H2O |
| Purity | 98% by HPLC |
| Synonym | GC376; GC-376; GC 376; GC376 sodium |
| IUPAC/Chemical Name | sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate |
| InChl Key | BSPJDKCMFIPBAW-JPBGFCRCSA-M |
| InChl Code | InChI=1S/C21H31N3O8S.Na/c1-13(2)10-16(24-21(28)32-12-14-6-4-3-5-7-14)19(26)23-17(20(27)33(29,30)31)11-15-8-9-22-18(15)25;/h3-7,13,15-17,20,27H,8-12H2,1-2H3,(H,22,25)(H,23,26)(H,24,28)(H,29,30,31);/q;+1/p-1/t15?,16-,17-,20?;/m0./s1 |
| SMILES Code | O=S(C(O)[C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)CC2C(NCC2)=O)([O-])=O.[Na+] |
| References | 1) Pedersen NC, et al. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis. J Feline Med Surg. 2018 Apr;20(4):378-392. 2) Takahashi D, et al. Structural andinhibitor studies of norovirus 3C-like proteases. Virus Res. 2013 Dec 26;178(2):437-44. |
More info
Novel 3C-like protease inhibitor for treating various forms of acquired feline infectious peritonitis
References (click to read) :
1) NO CLAIM TO CURE OR DRUG READINESS
2) An in-depth analysis of the UC Davis GC376 field study
3) Journal of Feline Medicine and Surgery 2018, Vol. 20(4) 378–392