Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	ABCC4
Gene ID:	10257
Uniprot ID:	MRP4_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes.
Post Translational Modifications	N-glycosylated.leading to substrate-selective effects on its transport activity.
Function	ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.
Protein Name	Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc Transporter Multi-Specific Organic Anion Transporter B Moat-B Multidrug Resistance-Associated Protein 4
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-382556 Reactome: R-HSA-9748787 Reactome: R-HSA-9753281
Cellular Localisation	Basolateral Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Its Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent
Alternative ELISA Names	Atp-Binding Cassette Sub-Family C Member 4 ELISA kit Mrp/Cmoat-Related Abc Transporter ELISA kit Multi-Specific Organic Anion Transporter B ELISA kit Moat-B ELISA kit Multidrug Resistance-Associated Protein 4 ELISA kit ABCC4 ELISA kit MOATB ELISA kit MRP4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance