Human Her2 (ERBB2) ELISA Kit
Referência EA200049
Tamanho : 1x96wells
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| Product Data | |
| Species | Human |
|---|---|
| Format | 8x12 divisible strips |
| Assay Type | Sandwich |
| Assay Length | 3.5 hours incubations; 0.5 hour washing and analyzing samples |
| Signal | Colorimetric |
| Curve Range | 78-5000pg/ml |
| Sample Type | Human serum, plasma and other biological fluids. |
| Sample Volume | 100µl |
| Specificity | This kit is used for quantitative detection of ErbB2/HER2 |
| Sensitivity | 31pg/ml |
| Reactivity | Human |
| Cross Reactivity | There is no detectable cross-reactivity with other relevant proteins. |
| Interference | No significant interference observed with available related molecules. |
| Components |
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| Background | ErbB2, also called Neu or Her2, is a transmembrane glycoprotein encoded by human Her-2 gene, which is closely related to the epidermal growth factor receptor protein. ErbB2 is a 185 kDa glycoprotein that contains an extracellular ligand-binding domain and intracellular tyrosine kinase activity. ErbB2 is widely expressed in low levels in epithelial cells of normal human tissues and over-expressed in some type of cancers. ErbB2 heterodimerizes with ErbB1/ErbB2, ErbB3, or ErbB4 to form higher affinity signaling complexes. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1) or NRG2. In these malignancies the HER-2 oncoprotein overexpression is correlated with a poor prognosis. Soluble forms of ErbB2 can be generated by proteolytic shedding or by alternative splicing. A 110 kDa soluble fragment of ErbB2 can be released by protease ADAM10 from the cell surface. Serum levels of soluble ErbB2 are elevated in individuals with Her2+ metastatic breast tumors and may be associated with survival. |
| Gene Symbol | ERBB2 |
| Locus ID | 2064 |
| Standard Curve |  |
| Shipping | Blue Ice |
| Datasheet | |
| Manual | |
| SDS | |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.