IL-17A is a member of the IL-17 family, which is comprised of 6 members [IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F]. IL-17 family members are involved in numerous immune regulatory functions, including inducing and mediating proinflammatory responses and allergic responses. IL-17 induces the production of many other cytokines (IL-6, G-CSF, GM-CSF, IL-1beta, TGF-beta, and TNF-alpha), chemokines, including IL-8 (CXCL8), GRO-alpha (CXCL1) and MCP-1 (CCL2) and prostaglandins from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages).

Reactivity - ELISA
Bovine IL-17A - Weak
Canine IL-17A - Strong
Caprine IL-17A - None
Cynomolgus Monkey - Moderate
Dolphin IL-17A - Moderate
Equine IL-17A - Moderate
Feline IL-17A - None
Ferret IL-17A - Moderate
Guinea Pig IL-17A - None
Human IL-17A - Strong
Mouse IL-17A - None

Rabbit IL-17A - Weak