IBMX

P019-100MG IBMX, 100 mg In Stock
P019-1GM IBMX, 1 gm In Stock
  • Features Pan-specific inhibitor of PDEs
  • Increases cellular cAMP and cGMP
  • Activates protein kinases
  • Storage at room temperature
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Product Protocol
Product SDS

IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50s from 7 to 50 µM for PDE1-5, PDE7, and PDE11. PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists. Suppresses alpha-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 µM).