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> IgdE protease [1892548-76-3]

IgdE protease [1892548-76-3]

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Referência HY-E70364-1KU

Tamanho : 1KU

Marca : MedChemExpress

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IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage.

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IgdE protease Chemical Structure

IgdE protease Chemical Structure

CAS No. : 1892548-76-3

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Description

IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage[1].

CAS No.

1892548-76-3
SMILES

[IgdE protease]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références

  • [1]. Faid V, et al., Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls. J Pharm Biomed Anal. 2018 Feb 5;149:541-546.  [Content Brief]

  • [1]. Faid V, et al., Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls. J Pharm Biomed Anal. 2018 Feb 5;149:541-546.

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IgdE protease Related Classifications

  • Inflammation/Immunology
  • Others
  • Biochemical Assay Reagents

  • Calculateur de molarité

  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IgdE protease1892548-76-3Biochemical Assay ReagentsIdeSmonoclonal antibodydisulfide bondssulfhydrylsInhibitorinhibitorinhibit