IN VIVO SILENCEMAG 1000 TRANSFECTION REAGENT
Referência IV-SM31000
Tamanho : 1000uL
Marca : OZ Biosciences
Contactar o distribuidor local :
Telefone : +1 850 650 7790
In vivo SilenceMag
In vivo SilenceMag™ is a rapid, simple and highly efficient method dedicated to transfect small RNA (siRNA, miRNA) into target cells/tissue in vivo. It combines magnetic nanoparticles and small RNA that will be retained after injection at the magnetically targeted site. This targeted delivery method minimizes systemic distribution, increases gene targeted inactivation and reduces toxicity. Furthermore, the magnetic forces enhance the uptake of magnetic nanoparticles by the target tissue, and thus improve the efficiency of silencing.
This allows decreasing the required process time of delivery to few minutes which is crucial for improvement of in vivo small RNA delivery. In vivo SilenceMag™ is designed to meet in vivo grade quality.
In vivo SilenceMag™ benefits:
- Increased silencing efficiency
- Targeted process (magnetically-driven)
- Reduction of the systemic dissemination of siRNA/miRNA during injection
- Reduction of the siRNA/miRNA doses
- Work under non permissive conditions (hypothermia, physiological flow conditions)
- Penetration of the siRNA/miRNA into tissues
- Minimized toxicity
Storage: +4°C
Shipping Conditions: Room temperature
- NB: This reagent needs to be used with a magnet
| Catalog number | Unit Size | excl tax | Quantity / Buy |
| IV-TK30240 | Trial kit: 100 µL reagent + 1 cylinder magnet | | |
| IV-KC30240 | Starting kit: 500 µL reagent + Magnets set | | |
| IV-SM30500 | 500 µL | | |
| IV-SM31000 | 1 mL | | |
IV-TK30240
Trial kit: 100 µL reagent + 1 cylinder magnet
IV-KC30240
Starting kit: 500 µL reagent + Magnets set
IV-SM30500
500 µL
IV-SM31000
1 mL
| NAME | MOLECULE VECTOR | PRODUCT | REFERENCE | |
| in vivo : hippocampus | siRNA | in vivo SilenceMag | Yang Y. Int Immunopharmacol. 2024 Jan 3:128:111380. | |
| in vivo : intra cerebellar | siRNA | in vivo SilenceMag | Liao Z. Int. J. Mol. Sci. 2023 24(19) 14693 | |
| in vivo : hippocampus | siRNA | in vivo SilenceMag | Zhang D. BMC Med . 2022 Jul 27;20(1):235. | |
| in vivo: sciatic nerve | siRNA | in vivo SilenceMag | Li J. Front. Mol. Neurosci. 27 August 2021. https://doi.org/10.3389/fnmol.2021.723395 | |
| in vivo: sciatic nerve | siRNA | in vivo SilenceMag | Zhang D. Prog Neurobiol 2021 Mar 22;102041. | |
| in vivo: subarachnoid space | siRNA | in vivo SilenceMag | Ou M. SSRN 2022 dx.doi.org/10.2139/ssrn.4191251 | |
| in vivo: Brain | siRNA | in vivo SilenceMag | Zhang M. Front. Neural Circuits Dec 2022 | |
| in vivo: Endothelial cells | siRNA | in vivo SilenceMag | Fujiu K. Nat Med. 2017 Apr 10. doi: 10.1038/nm.4326. | |
| in vivo: hepatocellular carcinoma | siRNA | in vivo SilenceMag | Yanhai Y. China Tropical Medicine 2018 vol 18 N°4 | |
| in vivo: hepatocellular carcinoma | siRNA | in vivo SilenceMag | Chen J. BMC Cancer. 2014 Feb 21;14(1):114. | |
| in vivo: intratechal injection | siRNA | in vivo SilenceMag | Xie H. EMBO Rep 2023 Sep 18:e56958. doi: 10.15252/embr.202356958. |