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> Lumisterol 3 (>90%) [5226-01-7]

Lumisterol 3 (>90%) [5226-01-7]

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Referência HY-112023-1mg

Tamanho : 1mg

Marca : MedChemExpress

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Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D.

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Lumisterol 3 (>90%) Chemical Structure

Lumisterol 3 (>90%) Chemical Structure

CAS No. : 5226-01-7

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Based on 1 publication(s) in Google Scholar

Description

Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D[1].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Lumisterol 3 (L3) (1-100 nM, 24 h) significantly reduces UVB-induced cellular oxidant formation in a dose-dependent manner and inhibits the proliferation of UVB-irradiated keratinocytes[2].
Lumisterol 3 (L3) (100 nM, 24 h) promotes repair of cellular DNA damage induced by UVB irradiation and increases the nuclear/cytosolic Nrf2 ratio and nuclear p53 expression level in UVB-irradiated cells[2].
Lumisterol 3 (L3) (100 nM, 3 h) significantly enhances the expression levels of Nrf2-regulated antioxidant proteins, including catalase and HO-1 in UVB-irradiated cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lumisterol 3 (>90%) Related Antibodies
Masse moléculaire

384.64

Formule

C27H44O
CAS No.

5226-01-7
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@@]12[C@](CC[C@]2(17)[C@H](C)CCCC(C)C)(17)C3=CC=C(C[C@@H](O)CC4)[C@]4(C)[C@]3(17)CC1
Structure Classification
  • Steroids
Initial Source
  • Endogenous metabolite
  • Human Gut Microbiota Metabolites
Livraison

Shipping with dry ice.
Stockage

-80°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvant et solubilité
In Vitro: 

DMSO : 2 mg/mL (5.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5998 mL 12.9992 mL 25.9983 mL
5 mM 0.5200 mL 2.5998 mL 5.1997 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 97.77%

SDS (393 KB)

COA (246 KB) HNMR (540 KB) RP-HPLC (322 KB)

Instruction de manipulation (2659 KB)
Références

  • [1]. Slominski AT, Li W, Kim TK, et al. Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol. 2015;151:25-37.  [Content Brief]

    [2]. Anyamanee Chaiprasongsuk, et al. Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms. Redox Biol. 2019 Jun;24:101206.  [Content Brief]

  • [1]. Slominski AT, Li W, Kim TK, et al. Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol. 2015;151:25-37.

    [2]. Anyamanee Chaiprasongsuk, et al. Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms. Redox Biol. 2019 Jun;24:101206.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5998 mL 12.9992 mL 25.9983 mL 64.9958 mL
5 mM 0.5200 mL 2.5998 mL 5.1997 mL 12.9992 mL
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Lumisterol 3 (>90%) Related Classifications

  • Metabolic Disease
  • Metabolic Enzyme/Protease
  • Endogenous Metabolite
Help & FAQs

Keywords:

Lumisterol 3 (>90%)5226-01-79β,10α-Cholesta-5,7-dien-3β-ol Cholecalciferol EP Impurity CEndogenous Metabolitephotochemicaltransformationskinpre-vitaminderivativeInhibitorinhibitorinhibit

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