Monoclonal Antibody to Ubiquitin (Clone: Ubi-1)

Figure-1: Formalin fixed paraffin embedded section of cerebral cortex of an Alzheimer patient processed with 34-1119 using HRP/DAB, giving a brown signal. Also stained with haemotoxylin in blue. A typical flame shaped tangle is seen in a pyramidal neuron in the center and is surrounded by some dystrophic neurites, also strongly ubiquitin positive. Both are commonly seen in cortical and hippocampal Alzheimer brain sections and are typical for this disease, but are rare or absent in healthy brain.