Mouse NGF (Nerve Growth Factor) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Ngf
Gene ID:	18049
Uniprot ID:	NGF_MOUSE
Sample Type:	serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Detected in submaxillary gland (at protein level). Highly expressed in male submaxillary gland. Levels are much lower in female submaxillary gland.
Post Translational Modifications
Function	Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.
Protein Name	Beta-Nerve Growth Factor Beta-Ngf
Database Links	Reactome: R-MMU-167060 Reactome: -MMU-170968 Reactome: -MMU-170984 Reactome: -MMU-177504 Reactome: -MMU-187042 Reactome: -MMU-198203 Reactome: -MMU-205017 Reactome: -MMU-205025 Reactome: -MMU-205043 Reactome: -MMU-209543 Reactome: -MMU-209560 Reactome: -MMU-209563
Cellular Localisation	Secreted Endosome Lumen Prongf Is Endocytosed After Binding To The Cell Surface Receptor Formed By Sort1 And Ngfr
Alternative ELISA Names	Beta-Nerve Growth Factor ELISA kit Beta-Ngf ELISA kit Ngf ELISA kit Ngfb ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance