NEUROD1 Antibody
Referência OAAJ06755
Tamanho : 100uL
Marca : Aviva Systems Biology
Contactar o distribuidor local :
Telefone : +1 850 650 7790
| Datasheets/Manuals | Printable datasheet for anti-NEUROD1 (OAAJ06755) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat |
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| Product Format | Liquid PBS (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Application | ICC, IF, IHC, WB |
| Reconstitution and Storage | Store at -20°C. Stable for 12 months from date of receipt. |
| Immunogen | A synthesized peptide derived from human NEUROD1, corresponding to a region within N-terminal amino acids. |
| Purification | Purified by peptide affinity chromatography |
| Concentration | 1 mg/mL |
| Specificity | NEUROD1 Antibody detects endogenous levels of total NEUROD1. |
| Application Info | WB: 1:500~2000 IHC: 1:50~200 IF/ICC: 1:100~500 P-ELISA: 1:20000~40000 |
| Gene Symbol | NEUROD1 |
|---|---|
| Alias Symbols | T2D, BETA2, BHF-1, MODY6, NEUROD, bHLHa3 |
| NCBI Gene Id | 4760 |
| Protein Name | Neurogenic differentiation factor 1 |
| Description of Target | NeuroD is a member of the basic helix-loop-helix (bHLH) family of transcription factors. These proteins function by forming heterodimers with E-proteins and binding to the canonical E-box sequence CANNTG. Neuronal activity results in CaMKII-mediated phosphorylation of NeuroD at Ser336, which is necessary for formation and growth of dendrites. NeuroD is also phosphorylated at Ser274 though the results are context dependent as phosphorylation by Erk stimulates NeuroD activity in pancreatic beta-cells while phosphorylation by GSK-3-beta inhibits NeuroD in neurons. NeuroD is crucially important in both the pancreas and developing nervous system, and plays a large role in the development of the inner ear and mammalian retina. Mice lacking NeuroD become severely diabetic and die shortly after birth due to defects in β-cell differentiation. The lack of NeuroD in the brain results in severe defects in development. Human mutations have been linked to a number of types of diabetes including type I diabetes mellitus and maturity-onset diabetes of the young |
| Uniprot ID | Q13562 |
| Protein Accession # | NP_002491 |
| Nucleotide Accession # | NM_002500 |
| Molecular Weight | 40 kDa |
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What is the species homology for "NEUROD1 Antibody (OAAJ06755)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".
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How long will it take to receive "NEUROD1 Antibody (OAAJ06755)"?
This item is available "Domestic: within 2-3 week delivery | International: 2-3 weeks".
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What buffer format is "NEUROD1 Antibody (OAAJ06755)" provided in?
This item is provided in "Liquid PBS (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol. ".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "NEUROD1 Antibody (OAAJ06755)"?
This target may also be called "T2D, BETA2, BHF-1, MODY6, NEUROD, bHLHa3" in publications.
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What is the shipping cost for "NEUROD1 Antibody (OAAJ06755)"?
The shipping cost for this item is within the US. Please contact us for specific shipping for international orders.
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What is the guarantee for "NEUROD1 Antibody (OAAJ06755)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "NEUROD1 Antibody (OAAJ06755)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "40 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "NEUROD1 Antibody (OAAJ06755)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "NEUROD1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "NEUROD1"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "NEUROD1"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "NEUROD1"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "NEUROD1"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "NEUROD1"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.