Poloxamer 188 (Highly Pure Surfactant)

Product Description

Poloxamer 188 (Highly Pure)
Catalog number: B2010444
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 mL
Molecular Weight or Concentration: 0.1
Supplied as: 10% Solution
Appearance: Solution
Applications: highly pure nonionic copolymer surfactant with applications in flow cytometry.
Storage: RT
Keywords: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Wang T, Markham A, Thomas SJ, Wang N, Huang L, Clemens M, Rajagopalan N.
Solution Stability of Poloxamer 188 Under Stress Conditions. J Pharm Sci. 2019
Mar;108(3):1264-1271.

2: Gibbs WJ, Hagemann TM. Purified poloxamer 188 for sickle cell vaso-occlusive
crisis. Ann Pharmacother. 2004 Feb;38(2):320-4.

3: Grapentin C, Müller C, Kishore RSK, Adler M, ElBialy I, Friess W, Huwyler J,
Khan TA. Protein-Polydimethylsiloxane Particles in Liquid Vial Monoclonal
Antibody Formulations Containing Poloxamer 188. J Pharm Sci. 2020
Aug;109(8):2393-2404.

4: Dong H, Qin Y, Huang Y, Ji D, Wu F. Poloxamer_188 rescues MPTP-induced
lysosomal membrane integrity impairment in cellular and mouse models of
Parkinson’s disease. Neurochem Int. 2019 Jun;126:178-186.

5: Moloughney JG, Weisleder N. Poloxamer_188 (p188) as a membrane resealing
reagent in biomedical applications. Recent Pat Biotechnol. 2012 Dec;6(3):200-11.

6: Mehdipour M, Daghigh Kia H, Martínez-Pastor F. Poloxamer_188 exerts a
cryoprotective effect on rooster sperm and allows decreasing glycerol
concentration in the freezing extender. Poult Sci. 2020 Nov;99(11):6212-6220.

7: Guler N, Abro S, Emanuele M, Iqbal O, Hoppensteadt D, Fareed J. The
Protective Effect of Poloxamer_188 on Platelet Functions. Clin Appl Thromb
Hemost. 2017 Nov;23(8):987-991.
8: Czeiszperger TL, Wang MP, Chung CS. Membrane stabilizer Poloxamer 188
improves yield of primary isolated rat cardiomyocytes without impairing
function. Physiol Rep. 2020 Feb;8(4):e14382.

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