Rat Anti Mouse CD8 Biotinylated

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Referência ant-281-1mg

Tamanho : 1mg

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Telefone : +1 850 650 7790

Marca : Prospec

Contactar o distribuidor local :

Telefone : +1 850 650 7790

Catalogue number

ANT-281

Synonyms

CD8, MAL, p32.

Type

Rat Anti Mouse Monoclonal.

Introduction

CD8 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 acts as a co-receptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional CD8 is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
CD8 identifies cytotoxic/suppressor t-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of t-cell mediated killing. CD8 alpha chains bind to class-I MHC molecules alpha-3 domains.

Clone

NYRmCD8.

Immunogen

Purified Mouse LN T cells.

Ig Subclass

Rat IgM.

Purification Method

Ion Exchange Column.

Formulation

1mg/ml in PBS (after reconstitution).

Storage Procedures

Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

Solubility

Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Applications

FACS staining, immunohistochemistry, Western Blotting. For staining, use 10 µl/1,000,000 cells.

Available Conjugates

This antibody is only available unconjugated and conjugated to FITC.

Safety Data Sheet

SDS

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.