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> Z-VAD-FMK [187389-52-2]

Z-VAD-FMK [187389-52-2]

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Referência 10-2614-1mg

Tamanho : 1mg

Marca : Focus Biomolecules

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Z-VAD-FMK | Caspase inhibitor

CAS:
187389-52-2
Catalog Number:
10-2614
Activity:
Caspase inhibitor
Alternate Names:
ZVAD(OMe)-FMK
Chemical Name:
Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Molecular Weight:
467.5
Molecular Formula:
C22H30FN3O7
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Lyophilized or waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT

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1 mg$98.00
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This product is also available in the following library:
Protease Inhibitors

Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.

References/Citations:

1) Slee et al. (1996), Benzyloxycarbonyl-Val-Ala-ASP (OMe) fluoromethylketone (Z-VAD-FMK) inhibits apoptosis by blocking the processing of CPP32; Biochem. J., 315 21
2) Kunstle et al. (1997), ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha; Immunol. Lett., 55 5
3) Garcia-Calvo et al. (1998), Inhibition of human caspases by peptide based and macromolecular inhibitors; J. Biol. Chem., 273 32608

CAS:
187389-52-2
Catalog Number:
10-2614
Activity:
Caspase inhibitor
Alternate Names:
ZVAD(OMe)-FMK
Chemical Name:
Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
Molecular Weight:
467.5
Molecular Formula:
C22H30FN3O7
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Lyophilized or waxy solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.

References/Citations:

1) Slee et al. (1996), Benzyloxycarbonyl-Val-Ala-ASP (OMe) fluoromethylketone (Z-VAD-FMK) inhibits apoptosis by blocking the processing of CPP32; Biochem. J., 315 21
2) Kunstle et al. (1997), ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha; Immunol. Lett., 55 5
3) Garcia-Calvo et al. (1998), Inhibition of human caspases by peptide based and macromolecular inhibitors; J. Biol. Chem., 273 32608

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A1902-1mg
Z-VAD-FMK [187389-52-2]
 1mg