![1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)](https://www.quimigen.pt/upload/bandeau3-9pw8hz2z-7wuq4zmd-b664f4-vbkwka.png)
1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)
POPG, or 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol), represents a distinct semi-synthetic lipid with a unique structural composition derived from palmitic and oleic acids, glycerol, and a racemic glycerol backbone. This composition imparts distinctive characteristics to POPG, making it a valuable asset in membrane research, particularly in studies focusing on lipid-protein interactions, membrane dynamics, and cellular processes.
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Palmitic and Oleic Acid Derivation: Synthesized from palmitic and oleic acids, POPG combines saturated and unsaturated fatty acids in its acyl chains.
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Racemic Glycerol Backbone: POPG is characterized by the presence of a racemic glycerol backbone, introducing an additional layer of structural diversity compared to conventional glycerophospholipids.
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Glycerol Headgroup: The glycerol headgroup of POPG renders it amphiphilic, contributing to its ability to form lipid bilayers and participate in membrane mimicking.
Applications in Membrane Research
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Influence on Lipid-Protein Interactions: The unique structural features of POPG, including its acyl chains and racemic glycerol backbone, make it an ideal candidate for investigating the influence of lipid composition on lipid-protein interactions in biological membranes.
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Membrane Mimicking: POPG, with its amphiphilic nature, is employed to mimic natural lipid bilayers, creating environments suitable for studying membrane dynamics and the behavior of proteins within lipid membranes.
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Cellular Process Exploration: Due to its relevance in cellular membranes, POPG finds applications in understanding cellular processes, contributing to research in cell biology and biochemistry.
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