Amphipol A8-35 Structure

For general laboratory use.

Shipping: shipped at ambient temperature

Storage Conditions: store at -20 °C

Shelf Life: 12 months

Molecular Formula: (C_6.2H_10.3O_1.35N_0.65Na_0.35)₇₂

Molecular Weight: approx. 9 kDa

CAS#: 326856-53-5

Applications:
Stabilizing agent in Cryo-EM^[2-5] and X-ray crystallography^[6]

Description:
Amphipol A8-35 is a short amphipatic polymer that is specifically designed for membrane protein stabilization. The surfactant possesses a very high affinity for the transmembrane surfaces and allows to solubilize membrane proteins in a detergent-free aqueous solution^[1].

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Selected References:
[1] Zoonens et al. (2014) Amphipols for Each Season. J Membrane Biol 247:759.
[2] Chen et al. (2016) Structure of the STRA6 receptor for retinol uptake. Science 353:887.
[3] Zubcevic et al. (2016) Cryo-Electron Microscopy of the Trpv2 Ion Channel. Nat Struct Mol Biol 23:180.
[4] Bai et al. (2015) Sampling the conformational space of the catalytic subunit of human gamma-secretase. DOI 10.7554/eLife.11182.
[5] Althoff et al. (2011) Arrangement of electron transport chain components in bovine mitochondrial supercomplex I₁III₂IV₁. EMBO J 30:4652.
[6] Polovinkin et al. (2014) High-Resolution Structure of a Membrane Protein Transferred from Amphipol to a Lipidic Mesophase. J Membrane Biol 247:997.