EX-527
P005-5MG EX-527, 5 mg In Stock
P005-25MG EX-527, 25 mg In Stock
- Features Selective SIRT1 inhibitor
- Does not inhibit HDACs
- Inhibitor of SIRT1 deacetylation of p53
EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM in vivo, 38nM in vitro) that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 20 uM, 49 uM, > 100 uM and > 100 uM for SIRT2, SIRT3, HDAC and NADase respectively). EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.