General Info
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.062ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This AHRR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
Information
| Gene Symbol: | AHRR |
| Gene ID: | 57491 |
| Uniprot ID: | AHRR_HUMAN |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Description
| Tissue Specificity | Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. |
| Post Translational Modifications | |
| Function | Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. |
| Protein Name | Aryl Hydrocarbon Receptor RepressorAhr RepressorAhrrClass E Basic Helix-Loop-Helix Protein 77Bhlhe77 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-211945Reactome: R-HSA-211976Reactome: R-HSA-211981Reactome: R-HSA-8937144 |
| Cellular Localisation | CytoplasmNucleusPredominantly In The Nuclear CompartmentFirst CytoplasmicTranslocates Into The Nuclear Compartment Upon Interaction With Arnt In The Cytoplasmic Compartment |
| Alternative ELISA Names | Aryl Hydrocarbon Receptor Repressor ELISA kitAhr Repressor ELISA kitAhrr ELISA kitClass E Basic Helix-Loop-Helix Protein 77 ELISA kitBhlhe77 ELISA kitAHRR ELISA kitBHLHE77 ELISA kitKIAA1234 ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance