Reagents and instruments for immunology, cell biology and molecular biology.
 
> IgdE protease [1892548-76-3]

IgdE protease [1892548-76-3]

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Cat# HY-E70364-1KU

Size : 1KU

Brand : MedChemExpress

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IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage.

For research use only. We do not sell to patients.

IgdE protease Chemical Structure

IgdE protease Chemical Structure

CAS No. : 1892548-76-3

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Description

IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage[1].

CAS No.

1892548-76-3
SMILES

[IgdE protease]
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References

  • [1]. Faid V, et al., Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls. J Pharm Biomed Anal. 2018 Feb 5;149:541-546.  [Content Brief]

  • [1]. Faid V, et al., Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls. J Pharm Biomed Anal. 2018 Feb 5;149:541-546.

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IgdE protease Related Classifications

  • Inflammation/Immunology
  • Others
  • Biochemical Assay Reagents

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IgdE protease1892548-76-3Biochemical Assay ReagentsIdeSmonoclonal antibodydisulfide bondssulfhydrylsInhibitorinhibitorinhibit