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> Thapsigargin [67526-95-8]

Thapsigargin [67526-95-8]

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Cat# 10-2105-1mg

Size : 1mg

Brand : Focus Biomolecules

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Thapsigargin | SERCA inhibitor

CAS:
67526-95-8
Catalog Number:
10-2105
Activity:
SERCA inhibitor
Chemical Name:
Isolated from Thapsia garganica
Molecular Weight:
650.77
Molecular Formula:
C34H50O12
Solubility:
Soluble in DMSO (up to 65 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Colorless waxy solid / film
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT

Available Options

Size : Quantity 
1 mg$60.00
5 mg$238.00
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Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase.1 (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines.2 Warning: Thapsigargin is highly irritating to skin and mucus membranes.

References/Citations:

1) Treiman et al. (1998), A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases; Trends Pharmacol. Sci., 19 131
2) Zhou et al. (2009), Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance; Mol. Pharmacol., 76 596

CAS:
67526-95-8
Catalog Number:
10-2105
Activity:
SERCA inhibitor
Chemical Name:
Isolated from Thapsia garganica
Molecular Weight:
650.77
Molecular Formula:
C34H50O12
Solubility:
Soluble in DMSO (up to 65 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Colorless waxy solid / film
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase.1 (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines.2 Warning: Thapsigargin is highly irritating to skin and mucus membranes.

References/Citations:

1) Treiman et al. (1998), A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases; Trends Pharmacol. Sci., 19 131
2) Zhou et al. (2009), Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance; Mol. Pharmacol., 76 596

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