![Anti-N-Cadherin CE/IVD for IHC - Dermopathology](https://www.quimigen.pt/en/upload/thumbs/n-cadherin-7d2ebu-043cbe.jpg)
Anti-N-Cadherin CE/IVD for IHC - Dermopathology
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
N-cadherin, also known as Cadherin-2 (CDH2) or Neural Cadherin (NCAD), is a transmembrane cell adhesion molecule that was originally detected in nervous tissue. It plays an important role in embryogenesis, being involved in gastrulation and neural crest development. N-cadherin is found is cancer cells and allows for transendothelial migration, which is a critical process in the metastasis of cancer. Overexpression and disorderly arrangement of N-cadherin has been noted in dilated cardiomyopathy. It has been suggested that, when considered in adjunct with the status of a number of additional cell-cell adhesion molecules, missense mutations in N-cadherin may be a potential indicator of obsessive-compulsive disorder and Tourette disorder.
![](/upload/n-cadherin-c141211a2-n-cadherin-s-hhtjap.jpg)
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Kidney section
Liver section
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