Reagents and instruments for immunology, cell biology and molecular biology.
 
Anti-S-100 CE/IVD for IHC - Neuropathology

Anti-S-100 CE/IVD for IHC - Neuropathology

The S100 protein family comprises low-molecular-weight calcium-binding proteins characterized by two EF-hand calcium-binding motifs. In diagnostic neuropathology, the term S100 protein generally refers to antibodies recognizing S100A1 and S100B subunits, which form homo- and heterodimers predominantly expressed in glial cells, Schwann cells, melanocytes, and other neural crest-derived cell populations. S100 proteins regulate calcium homeostasis, cytoskeletal dynamics, cellular differentiation, proliferation, migration, and survival through intracellular signaling and extracellular receptor-mediated pathways. Within the central and peripheral nervous systems, S100 proteins are highly expressed in astrocytes, Schwann cells, satellite glial cells, ependymal cells, sustentacular cells, and other glial populations.

Biological Significance of S100 Protein

  • Highly expressed in astrocytes, Schwann cells, satellite glial cells, and other glial populations.
  • Functions as a regulator of intracellular calcium signaling, cytoskeletal organization, and cellular homeostasis.
  • Participates in neuronal development, myelination, neuroinflammation, tissue repair, and cellular stress responses.
  • Extracellular S100 proteins may act as cytokine-like mediators through activation of receptors such as RAGE and Toll-like receptors (TLRs).

Diagnostic Utility of S100 Protein in Neuropathology

Sensitive marker of Schwann cell lineage differentiation in:

  • Schwannoma.
  • Neurofibroma.
  • Granular cell tumor.

Supports the diagnosis of malignant peripheral nerve sheath tumor (MPNST), although staining may be focal, heterogeneous, or reduced in high-grade lesions.

Useful as a sensitive but relatively non-specific marker of astrocytic and Schwannian differentiation, particularly when interpreted alongside lineage-specific markers such as GFAP, OLIG2, and SOX10.

Commonly incorporated into antibody panels for the evaluation of melanocytic tumors, clear cell sarcoma, and selected dendritic or histiocytic proliferations involving the nervous system.

Key Features of CE/IVD Anti-S100 Antibodies

  • Validated for formalin-fixed paraffin-embedded (FFPE) tissue sections.
  • Optimized for automated and manual immunohistochemistry platforms.
  • Typically demonstrate nuclear and cytoplasmic immunoreactivity in positive cells according to the manufacturer's validated protocol.
  • High analytical sensitivity for detecting glial and Schwann cell populations.
  • Manufactured in compliance with CE/IVD regulatory requirements to support routine clinical diagnostics and standardized laboratory workflows.

 

Skin section
Melanoma section

 

Frequently Asked Questions (FAQ)

How can I quickly find a s-100 product?

To find a s-100 product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Quimigen stock several product codes in the s-100 category?

Yes, Quimigen distributes several product references in the s-100 category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for s-100 products?

Yes, you can request a quote for s-100 products from the product page or by contacting Quimigen (info@quimigen.pt). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a s-100 product is available to order?

The availability of a s-100 product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Quimigen with the product code or name of the product you are looking for.

What should I do if I cannot find the s-100 product I am looking for?

If the s-100 product you are looking for does not appear in the catalogue, please contact Quimigen with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all s-100 products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.

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