The protein encoded by MAML2 gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling.

The mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. With about 30-50% of all cases, the translocation t(11;19) (q21;p13.1) is the most frequent chromosomal aberration in mucoepidermoid carcinomas. In some cases the t(11;19) is the sole chromosomal anomaly and in other cases the t(11;19) was found either as a more complex translocation involving other chromosomes or together with other abnormalities.