Almitrine mesylate [29608-49-9]
Cat# HY-107319-10mg
Size : 10mg
Brand : MedChemExpress
Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel.
For research use only. We do not sell to patients.
Almitrine mesylate Chemical Structure
CAS No. : 29608-49-9
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel. |
IC50 & Target |
K+ channel[1] |
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In Vitro |
Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca2+-dependent K+ channel by decreasing its open probability. The IC50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca2+-dependent K+ channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K+, Ca2+, or Na+ currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca2+-dependent component of K+ currents in rat chemoreceptor cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
669.76 |
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Formula |
C28H37F2N7O6S2 |
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CAS No. |
29608-49-9 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
C=CCNC1=NC(N(CC2)CCN2C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)=NC(NCC=C)=N1.O=S(O)(C)=O.O=S(O)(C)=O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (149.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.81% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.4931 mL | 7.4654 mL | 14.9307 mL | 37.3268 mL |
5 mM | 0.2986 mL | 1.4931 mL | 2.9861 mL | 7.4654 mL | |
10 mM | 0.1493 mL | 0.7465 mL | 1.4931 mL | 3.7327 mL | |
15 mM | 0.0995 mL | 0.4977 mL | 0.9954 mL | 2.4885 mL | |
20 mM | 0.0747 mL | 0.3733 mL | 0.7465 mL | 1.8663 mL | |
25 mM | 0.0597 mL | 0.2986 mL | 0.5972 mL | 1.4931 mL | |
30 mM | 0.0498 mL | 0.2488 mL | 0.4977 mL | 1.2442 mL | |
40 mM | 0.0373 mL | 0.1866 mL | 0.3733 mL | 0.9332 mL | |
50 mM | 0.0299 mL | 0.1493 mL | 0.2986 mL | 0.7465 mL | |
60 mM | 0.0249 mL | 0.1244 mL | 0.2488 mL | 0.6221 mL | |
80 mM | 0.0187 mL | 0.0933 mL | 0.1866 mL | 0.4666 mL | |
100 mM | 0.0149 mL | 0.0747 mL | 0.1493 mL | 0.3733 mL |
Almitrine mesylate Related Classifications
- Membrane Transporter/Ion Channel
- Potassium Channel