General Info
Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-BPI (248-487) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | BPI |
Gene ID: | 671 |
Uniprot ID: | BPI_HUMAN |
Immunogen Region: | 248-487 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 248-487 of human BPI (NP_001716.2). |
Immunogen Sequence: | AETLDVQMKGEFYSENHHNP PPFAPPVMEFPAAHDRMVYL GLSDYFFNTAGLVYQEAGVL KMTLRDDMIPKESKFRLTTK FFGTFLPEVAKKFPNMKIQI HVSASTPPHLSVQPTGLTFY PAVDVQAFAVLPNSSLASLF LIGMHTTGSMEVSAESNRLV GELKLDRLLLELKHSNIGPF PVELLQDIMNYIVPILVLPR VNEKLQKGFPLPTPARVQLY NVVLQPHQNFLLFGADVVY |
Description
Tissue Specificity | Restricted to cells of the myeloid series. |
Function | The cytotoxic action of BPI is limited to many species of Gram-negative bacteria.this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. |
Protein Name | Bactericidal Permeability-Increasing ProteinBpiCap 57 |
Database Links | Reactome: R-HSA-166016Reactome: R-HSA-6798695Reactome: R-HSA-6803157 |
Cellular Localisation | SecretedCytoplasmic Granule MembraneMembrane-Associated In Polymorphonuclear Leukocytes (Pmn) Granules |
Alternative Antibody Names | Anti-Bactericidal Permeability-Increasing Protein antibodyAnti-Bpi antibodyAnti-Cap 57 antibodyAnti-BPI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance