General Info
| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Killer cell lectin-like receptor subfamily B member 1 is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | HP-3G10 |
| Conjugation: | APC |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.05% Proclin300, 1% BSA |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
| Gene Symbol: | KLRB1 |
| Gene ID: | 3820 |
| Uniprot ID: | KLRB1_HUMAN |
Description
| Tissue Specificity | Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily B Member 1C-Type Lectin Domain Family 5 Member BHnkr-P1aNkr-P1aNatural Killer Cell Surface Protein P1aCd Antigen Cd161 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Killer Cell Lectin-Like Receptor Subfamily B Member 1 antibodyAnti-C-Type Lectin Domain Family 5 Member B antibodyAnti-Hnkr-P1a antibodyAnti-Nkr-P1a antibodyAnti-Natural Killer Cell Surface Protein P1a antibodyAnti-Cd Antigen Cd161 antibodyAnti-KLRB1 antibodyAnti-CLEC5B antibodyAnti-NKRP1A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance