Anti-Flavocytochrome b558 (Human) mAb-FITC
Cat# D162-4
Size : 50ug
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Please Note: MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: https://www.cosmobiousa.com/. For Non-US inquiries reach out to MBL in Japan: https://www.mblbio.com/.
| Target | Flavocytochrome b558 |
|---|---|
| Product Type | Antibody |
| Application | FCM |
| Clonality | Monoclonal |
| Conjugate | FITC |
| Isotype | IgG1 |
| Immunogen | Rich fraction of human cytochrome b<sub>558</sub> |
| Host Species | Mouse |
| Species Reactivity | Human |
| Formulation | 50 % BSA and 0.1% ProClin 150. |
| Research Area | Cell Biology |
| Description/Background | The NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O2 to generate superoxide (O2-), a key part of the phagocytic or neutrophilic respiratory burst response. Flavocytochrome b558 is the catalytic component of the phagocyte NADPH oxidase. It is a transmembrane heterodimer composed of a large glycoprotein, gp91phox (PHagocyte OXidase) and a smaller protein, p22phox. Upon cell stimulation, flavocytochrome b558 assembles with p67phox, p47phox, and the GTP-binding protein Rac and becomes activated to generate O2-. Mutations in gp91phox, p22phox, or other components of the NADPH oxidase can result in chronic granulomatous disease, which is associated with significant morbidity and mortality due to a predisposition to recurrent bacterial and fungal infections. |
| Storage Temperature | 4D5 |
| Concentration | 0.5 mg/mL |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
D162-4
Antibody
100 uL