Anti-Human Caspase-3 - DyLight® 488
Cat# C1768-100
Size : 100µg
Brand : Leinco Technologies
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Phone : +1 850 650 7790
AntiHuman Caspase3 – DyLight® 488
AntiHuman Caspase3 – DyLight® 488
Product No.: C1768
Clone C31.129 Target Caspase3 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names p17, Caspase3 Active Subunit Isotype IgG1 Applications FC |
Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Purified Recombinant Human CASP3 (>98%) Product Concentration 0.2 mg/ml Formulation This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 488 conjugate is stable when stored at 28°C. Do not freeze. Country of Origin USA Shipping Next Day 28°C Excitation Laser Blue Laser (493 nm) RRIDAB_2828834 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse AntiHuman Caspase3 Active Subunit (p17) (CASP3) (Clone C31.129) recognizes an epitope on Human CASP3. This monoclonal antibody was purified using multistep affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Caspase3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1,2 Caspase3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3 PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Adadah, BA. et al. (2000) Journal of Neurotoma 17(10): 811 2. Salvesen, GS. et al. (1999) Proc. Natl. Acad. Sci. USA 96(20): 10964 3. Slee, EA. et al. (2001) J. Biol. Chem. 276(10):7320 |