Anti-LRRC32 (Plato-1) Antibody
Cat# OAED00392
Size : 100ug
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
Anti-LRRC32 (Plato-1) Antibody (OAED00392)
| Datasheets/Manuals | Printable datasheet for Anti-LRRC32 (Plato-1) Antibody (OAED00392) |
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| Predicted Species Reactivity | Human |
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| Product Format | LiquidPBS containing 50% glycerol and 0.02% sodium azide |
| Clonality | Monoclonal |
| Clone | Plato-1 |
| Isotype | IgG2b |
| Host | Mouse |
| Application | Enzyme-linked immunosorbent assay|Immunoprecipitation|Western blot |
| Additional Information | 1 test means: 1 uL of MAb is used to stain 500,000 cells in a sample volume of 50 uL. |
| Reconstitution and Storage | Store at 4°C short-term. For long-term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Protect from light. Stable for at least 1 year after receipt when stored at -20°C. |
| Immunogen | Recombinant human LRRC32 (aa 20-627). |
| Purification | Protein G-affinity purified |
| Concentration | 1 mg/ml |
| Specificity | Recognizes human and mouse LRRC32. |
| Source | Purified from concentrated hybridoma tissue culture supernatant. |
| Application Info | IP: 1:200 WB: 1:1,000 Cited applications include flow cytometry. Optimal dilutions should be determined by the end user. |
| Reference | Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8: J. Stockis, et al.; PNAS 114, E10161 (2017) A key role of GARP in the immune suppressive tumor microenvironment: S.A. Hahn, et al.; Oncotarget 7, 42996 (2016), Application(s): Western blot Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer: A. Metelli, et al.; Cancer Res. 76, 7106 (2016) Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells: C. Huygens, et al.; J. Biol. Chem. 290, 20105 (2015) |
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| Gene Symbol | LRRC32 |
| Gene Full Name | leucine rich repeat containing 32 |
| Alias Symbols | CPPRDD;D11S833E;GARP;garpin;glycoprotein A repetitions predominant;leucine-rich repeat-containing protein 32;transforming growth factor beta activator LRRC32. |
| NCBI Gene Id | 2615 |
| Protein Name | Leucine-rich repeat-containing protein 32 |
| Description of Target | LRRC32 (leucine rich repeat containing 32; also known as GARP or Garpin; Glycoprotein A repetitions predominant) is a glycoprotein expressed on the cell surface of megakaryocytes, platelets and activated regulatory T (Treg) cells. |
| Uniprot ID | Q14392 |
| Molecular Weight | Detects a band of ~100kDa (Fc Fusion OPED00084) by Western blot. Native protein is ~72kDa. |
