Apolipoprotein H / Apo H Human Protein
Cat# BA1044
Size : 1mg
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Apolipoprotein H / Apo H Human Protein
SKU
BA1044
Apolipoprotein H / Apo H human protein, 1 mg
2 Weeks*
| Product Data | |
| Species | Human |
|---|---|
| Protein Source | Plasma |
| Concentration | lot specific |
| Purity | >95% >95 % pure (SDS-PAGE). |
| presentation_state | Purified |
| Buffer | Presentation State: Purified State: Liquid protein purified by column chromatography. Buffer System: 20 mM HEPES-NaOH, 0.16 M Sodium Chloride, pH 7.5 with 0.1 mM PMSF, 20% glycerol, containing 0.1% bromo-nitro-dioxane/methylisothiazoline as preservative |
| Preparation | Liquid protein purified by column chromatography. |
| Application | ELISA: 0.4-0.8 µg/well. After thawing, mix thoroughly by vortexing before use! |
| Protein Description | Highy pure Beta 2 Glycoprotein I also known as Apolipoprotein H. Human IgA, IgG and IgM are not detectable by Western blot. |
| Note | Caution: All human source materials have tested negative for HIV1, HIV2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious. |
| Storage | Store the antigen at -20 °C or -70 °C. Avoid multiple freeze/thaw cycles. |
| Stability | Shelf life: six months from despatch. |
| Reference Data | |
| RefSeq | NP_000033 |
| Locus ID | 350 |
| Cytogenetics | 17q24.2 |
| Synonyms | Beta-2-glycoprotein I, Beta2GPI, B2GPI, ApoH, Apo-H, APC Inhibitor, Anticardiolipin Cofactor, B2G1 |
| Summary | Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019] |
| Protein Families | ELISA: 0.4-0.8 µg/well.<br />After thawing, mix thoroughly by vortexing before use! |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.