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> BAX monoclonal antibody, clone BAX/962

BAX monoclonal antibody, clone BAX/962

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Cat# MAB13415

Size : 100ug

Brand : Abnova

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Phone : +1 850 650 7790

  • Specifications

    Product Description

    Mouse monoclonal antibody raised against full length recombinant human BAX.MAB,monoclonal Ab,monoclonal antibody

    Immunogen

    Recombinant protein corresponding to full length human BAX.

    Host

    Mouse

    Theoretical MW (kDa)

    21

    Reactivity

    Human

    Specificity

    This monoclonal antibody is highly specific to Bax and shows no cross-reaction with Bcl-2 or Bcl-X protein.

    Form

    Liquid

    Purification

    Protein A/G purification

    Isotype

    IgG1

    Recommend Usage

    Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)
    Immunofluorescence (1-2 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
    Western Blot (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In 10 mM PBS (0.05% BSA, 0.05% sodium azide).

    Storage Instruction

    Store at 4°C.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Western Blot

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of Hodgkin's lymphoma (A) and human melanoma (B) with BAX monoclonal antibody, clone BAX/962 (Cat # MAB13415).

    Immunofluorescence

    Flow Cytometry

  • Gene Info class="font-18 semiblod">Entrez GeneID 581

    Protein Accession#

    Q07812

    Gene Name

    BAX

    Gene Alias

    BCL2L4

    Gene Description

    BCL2-associated X protein

    Omim ID

    600040

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq

    Other Designations

    apoptosis regulator BAX

  • Interactomes
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