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> BZ1 [2766623-38-3]

BZ1 [2766623-38-3]

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Cat# 10-4037-25mg

Size : 25mg

Brand : Focus Biomolecules

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BZ1 | BPTF inhibitor

CAS:
2766623-38-3
Catalog Number:
10-4037
Activity:
BPTF inhibitor
Chemical Names:
5-((4-(2-Aminoethyl)phenyl)amino)-4-chloro-2-methylpyridazin-3(2H)-one
Molecular Weight:
278.74
Molecular Formula:
C13H15ClN4O
Solubility:
Soluble in DMSO (>50 mg/ml); ethanol (>50 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Available Options

Size: Quantity 
5 mg$65.00
25 mg$250.00
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BZ1 (2766623-38-3) is a potent (Kd = 6.3 nM; IC50 = 67 nM BPTF Alphascreen) inhibitor of the bromodomain PHD finger transcription factor (BPTF).  It displays >350-fold selectivity over BET bromodomains. BZ1 sensitized 4T1 mouse breast cancer cells to doxorubicin treatment.  BPTF inhibition represents a potential strategy for the inhibition of nucleosome remodeling factor (NURF) and exploration of its function.

References/Citations:

  1. Zahid et al. (2021), New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition; J. Med. Chem. 64 13902
CAS:
2766623-38-3
Catalog Number:
10-4037
Activity:
BPTF inhibitor
Chemical Names:
5-((4-(2-Aminoethyl)phenyl)amino)-4-chloro-2-methylpyridazin-3(2H)-one
Molecular Weight:
278.74
Molecular Formula:
C13H15ClN4O
Solubility:
Soluble in DMSO (>50 mg/ml); ethanol (>50 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

BZ1 (2766623-38-3) is a potent (Kd = 6.3 nM; IC50 = 67 nM BPTF Alphascreen) inhibitor of the bromodomain PHD finger transcription factor (BPTF).  It displays >350-fold selectivity over BET bromodomains. BZ1 sensitized 4T1 mouse breast cancer cells to doxorubicin treatment.  BPTF inhibition represents a potential strategy for the inhibition of nucleosome remodeling factor (NURF) and exploration of its function.

References/Citations:

  1. Zahid et al. (2021), New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition; J. Med. Chem. 64 13902