Application
| WB, IHC-P, E |
|---|---|
| Primary Accession | P09603 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 2D10 |
| Calculated MW | 60kDa |
| Dilution | IHC-P (1:200), WB (1:500-1:2000), |
| Gene ID | 1435 |
|---|---|
| Other Names | Macrophage colony-stimulating factor 1, CSF-1, M-CSF, MCSF, Lanimostim, Processed macrophage colony-stimulating factor 1, CSF1 |
| Target/Specificity | Human CSF1 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | CSF1 / MCSF Antibody (clone 2D10) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CSF1 |
|---|---|
| Function | Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
References
Kawasaki E.S.,et al.Science 230:291-296(1985).
Wong G.G.,et al.Science 235:1504-1508(1987).
Cerretti D.P.,et al.Mol. Immunol. 25:761-770(1988).
Takahashi M.,et al.Biochem. Biophys. Res. Commun. 161:892-901(1989).
Ota T.,et al.Nat. Genet. 36:40-45(2004).