Cyanocobalamin (Vitamin B12)

Cat# C8400-1g

Size : 1g

Brand : US Biological

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C8400 Cyanocobalamin (Vitamin B12)

Clone Type
Polyclonal
Grade
Cell Culture Grade
Shipping Temp
RT
Storage Temp
4°C

Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the β-ligand of the cobalt are termed cobalamins. Synthesized almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment.||Synonyms:|5,6-Dimethyl-1-(3-O-phosphono-α-D-ribofuranosyl)-1H-benzimidazole Monoester Cobinamide Cyanide Inner Salt; 5,6-Dimethylbenzimidazolyl Cyanocobamide; 5,6-Dimethylbenzimidazolyl-Co-cyanocobamide; Anacobin; Antipernicin; Apikobal; B-Twelve; B-Twelve Ora; Bedodeka; Bedoz; Behepan; Berubi; Berubigen; Dobetin; Docemine; Docibin; Poyamin; Rebramin; Redamina; Vitarubin; Vitral||CAS No:|68-19-9||Molecular Formula:|C63H88CoN14O14P||Molecular Weight:|1355.38||Purity:|≥97%||Appearance:|Dark red crystalline powder||Identification:|Conforms to USP reference||Loss on Drying:|≤10%||Residual Solvents (Acetone):|≤0.5%||Psuedo Cyanocobalamin:|Conforms to USP||Total Plate Count:|≤1000cfu/g ||Yeast and Mold:|≤100cfu/g ||E. coli:|Negative||Meets or exceeds USP specifications

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
References
US Biological reference:|Chan W., et al. 2017. Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B12-Deprivation Optic Neuropathy. Am J Pathol. pii: S0002-9440(17)30324-3. doi: 10.1016/j.ajpath.2017.08.032. [Epub ahead of print].|1. Rickes, et al., Science, 107, 396 (1948)|2. Kirschbaum, J., et al., Anal. Profiles Drug Subs., 10, 183 (1981)|3. Grasbeck, R., et al., Clin. Biochem., 17, 99 (1984)|4. Chan W., et al. 2017. Am J Pathol. pii: S0002-9440(17)30324-3. doi: 10.1016/j.ajpath.2017.08.032. [Epub ahead of print].

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