Cynomolgus Monkey CXCL10 Polyclonal Antibody - Biotinylated

C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is a member of the C-X-C chemokine family. CXCL10 (IP-10) is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL10 (IP-10) elicits its effects by binding to the cell surface chemokine receptor CXCR3.

Reactivity - ELISA
Bovine CXCL10 - None
Canine CXCL10 - None
Caprine CXCL10 - None
Cynomolgus Monkey CXCL10 - Strong
Dolphin CXCL10 - None
Equine CXCL10 - None
Feline CXCL10 - None
Guinea Pig CXCL10 - None
Human CXCL10 - Strong
Mouse CXCL10 - None
Ovine CXCL10 - None
Rabbit CXCL10 - None
Rat CXCL10 - None
Swine CXCL10 - None