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> Diltiazem [33286-22-5]

Diltiazem [33286-22-5]

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Cat# 10-1139-1g

Size : 1g

Brand : Focus Biomolecules

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Diltiazem | Calcium channel blocker

CAS:
33286-22-5
Catalog Number:
10-1139
Activity:
Calcium channel blocker
Chemical Name:
(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one hydrochloride
Molecular Weight:
450.98
Molecular Formula:
C22H26N2O4S • HCl
Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Water (up to 50 mg/ml)
Physical Properties:
White or off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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1 gram$50.00
5 gram$140.00
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Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels.1,2 Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells.3 Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons.4 Clinically useful antihypertensive agent.5 Cell permeable.

References/Citations:

1) Kraus et al. (1998), Molecular mechanism of diltiazem interaction with L-type Ca2+ channels; J. Biol. Chem., 273 27205
2) Godfraind et al. (1986), Calcium antagonism and calcium entry blockade; Pharmacol. Rev., 38 321
3) Fedoryak et al. (2004), Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools; Cell Res., 14 379
4) Ishibashi et al. (1995), Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil; Brain Res., 695 88
5) Chaffman and Bogden (1985), Diltiazem. A review of its pharmacological properties and therapeutic efficacy; Drugs, 29 387

CAS:
33286-22-5
Catalog Number:
10-1139
Activity:
Calcium channel blocker
Chemical Name:
(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one hydrochloride
Molecular Weight:
450.98
Molecular Formula:
C22H26N2O4S • HCl
Solubility:
Soluble in DMSO (up to 45 mg/ml) or in Water (up to 50 mg/ml)
Physical Properties:
White or off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

Diltiazem HCl (33286-22-5) is a non-dihydropyridine-type blocker of L-type Ca2+ channels.1,2 Reduces Ca2+ oscillations in subcellular compartments in vascular smooth muscle cells.3 Also blocks P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons.4 Clinically useful antihypertensive agent.5 Cell permeable.

References/Citations:

1) Kraus et al. (1998), Molecular mechanism of diltiazem interaction with L-type Ca2+ channels; J. Biol. Chem., 273 27205
2) Godfraind et al. (1986), Calcium antagonism and calcium entry blockade; Pharmacol. Rev., 38 321
3) Fedoryak et al. (2004), Spontaneous Ca2+ oscillations in subcellular compartments of vascular smooth muscle cells rely on different Ca2+ pools; Cell Res., 14 379
4) Ishibashi et al. (1995), Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil; Brain Res., 695 88
5) Chaffman and Bogden (1985), Diltiazem. A review of its pharmacological properties and therapeutic efficacy; Drugs, 29 387