Aminoglycoside antibiotic complex from Micromonospora purpurea.
Consists of closely related compounds: gentamycin C₁, C_1a, C₂, C_2a and C_2b. Inhibits bacterial protein synthesis by binding to the ribosomal 30S subunit and causing misreading of mRNA (in a similar way as streptomycin).
Broad spectrum antibiotic which inhibits growth of many gram positive and gram negative bacteria including strains which are resistant to chloramphenicol, kanamycin or tetracycline. Frequently used in cell culture, often in combination with amphotericin B, nystatin or penicillin G (1,3).
Min. 590 U/mg gentamycin base/g.


References:

1. Watts, J.W. & King, J.M. (1973) Planta 113, 271-7
2. Cox, D. et al. (1977) in: Sammes, P.G. (ed.) Topics in antibiotics chemistry Vol. I Chichester: Horwood, pp. 1-90
3. Eichholtz, D.A. et al. (1979) Plant Physiol. 63, Abstr. 753
4. Lancini, G. & Parenti, F. (1982) Antibiotics; Springer, New York
5. Nakamura, T. et al. (1991) J. Biol. Chem. 266, 19432-7
6. Stubbs, A.C. et al. (2001) Nature Medicine 7, 625-9
7. Manevich, Y. et al. (2002) PNAS 99, 11599-604
8. Richard, J.P. et al. (2005) J. Biol. Chem. 280, 15300-6

DANGER

Hazard Statements	H317 - H334
Precautions	P261 - P280
Reaction	P302 +P352 - P304 +P340 - P333 +P313 - P342 +P311

EINECS: 215-778-9 • WGK: 1 • HS: 29419000
Storage Temperature: +15 °C to +30 °C