Tumor necrosis factor alpha (TNFSF2) is a member of the TNF Superfamily. It is produced chiefly by activated macrophages, but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neuronal tissue. The primary role of TNF alpha is in the regulation of immune cells. TNF alpha, being an endogenous pyrogen, is able to induce fever, to induce apoptotic cell death, to induce sepsis (through IL-1 & IL-6 production), to induce cachexia, induce inflammation, and to inhibit tumorigenesis and viral replication.

Reactivity - ELISA
Bovine TNF-α - None
Canine TNF-α - None
Dolphin TNF-α - None
Equine TNF-α - None
Feline TNF-α - None
Guinea Pig TNF-α - Strong
Human TNF-α - None
Mouse TNF-α - Weak
Ovine TNF-α - Weak
Rabbit TNF-α - Weak
Swine TNF-α - None